CATEGORY:
Research
SCREENSHOT:
TITLE:
Expression of alpha2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss
CONTENT:
Curr Med Sci. 2021 Feb;41(1):153-157. doi: 10.1007/s11596-021-2330-5. Epub 2021 Feb 13.
ABSTRACT
K+ cycling in the cochlea is critical to maintain hearing. Many sodium-potassium pumps are proved to participate in K+ cycling, such as Na/K-ATPase. The α2-Na/K-ATPase is an important isoform of Na/K-ATPase. The expression of α2-Na/K-ATPase in the cochlea is not clear. In this study, we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR, and the α2-Na/K-ATPase expression pattern was confirmed in the inner ear. It was found α2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging (4-, 14-, 26- and 48-weeks old mice). We suspected that, the down-regulation of α2-Na/K-ATPase expression might be associated with the remodeling of K+ cycling, degeneration of morphological structure and decrease of hearing function in aging C57 mice. In conclusion, we speculated that the reduction of α2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss.
PMID:33582920 | DOI:10.1007/s11596-021-2330-5
SOURCE:
Current medical science
PUBLISHER:
PMID:
pubmed:33582920
ID:
0b58ea4968e09ff10f4e1238c494f316pubmed:33582920
DOI:
10.1007/s11596-021-2330-5
DATE – PUBLISHED:
Sun, 14 Feb 2021 06:00:00 -0500
DATE – DOI:
2021-02-14T09:43:18Z
DATE – ADDED:
02/15/21 01:12AM
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33582920/
LINK – DOI:
https://doi.org/10.1007/s11596-021-2330-5
LINK – PUBLISHER:
http://link.springer.com/10.1007/s11596-021-2330-5
IMAGE:
REFERENCE:
Hearing Loss Treatment Report, Urgent Research, 2021-02-15T06:12:41+00:00, https://www.hearinglosstreatmentreport.com.