inner ear organoids

Greater epithelial ridge cells display robust potential to generate inner ear organoids

January 19, 2021

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31635-1

https://pubmed.ncbi.nlm.nih.gov/33472062/

Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea

Greater epithelial ridge cells display robust potential to generate inner ear organoids

Building inner ears: recent advances and future challenges for in vitro organoid systems

December 14, 2020

https://www.nature.com/articles/s41418-020-00678-8

Building inner ears: recent advances and future challenges for in vitro organoid systems
Wouter H. van der Valk, Matthew R. Steinhart, Jingyuan Zhang & Karl R. Koehler
Cell Death & Differentiation volume 28, pages24–34(2021)Cite this article

Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration

September 2, 2019

https://dev.biologists.org/content/146/17/dev177188

https://www.ncbi.nlm.nih.gov/pubmed/31477580?dopt=Abstract

Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.

Development. 2019 09 02;146(17):

Authors: Roccio M, Edge ASB

Abstract

The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.

PMID: 31477580 [PubMed – indexed for MEDLINE]